KEMRI Institutional Repository: Recent submissions

Now showing items 861-880 of 1655

Tackling the triple threats of childhood malnutrition

Mwangome M, Prentice AM (BMC Medicine, 2019-11)

The term 'double burden of malnutrition' is usually interpreted in terms of the physical status of children: stunted and wasted children on the one hand and overweight/obese children on the other. There is a third category ...
Implementing a quality management system using good clinical laboratory practice guidelines at KEMRI-CMR to support medical research

Gumba H, Waichungo J, Lowe B, Mwanzu A, Musyimi R, Thitiri J, Tigoi C, Kamui M, Berkley JA, Ngetich R, Kavai S, Kariuki S (Wellcome Open Research, 2019-06)

Background: Good Clinical Laboratory Practice (GCLP) is a standard that helps ensure the quality and reliability of research data through principles of Good Laboratory Practice (GLP) and Good Clinical Practice (GCP). The ...
A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: A double-blind, randomized controlled trial

Bandsma RHJ, Voskuijl W, Chimwezi E, Fegan G, Briend A, Thitiri J, Ngari M, Mwalekwa L, Bandika V, Ali R, Hamid F, Owor B, Mturi N, Potani I, Allubha B, Muller Kobold AC, Bartels RH, Versloot CJ, Feenstra M, van den Brink DA, van Rheenen PF, Kerac M, Bourdon C, Berkley JA (PLOS One Journals, 2019-02)

Background: Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality and ...
Research Dissemination Strategies Used by Kenya Medical Research Institute Scientists

Kariuki JN, Kaburi J, Musuva R, Njomo DW, Night D, Wandera C, Wodera J, Mwinzi PN (The East African Health Research Journal, 2019-07)

Background: Dissemination of research findings is acknowledged as an important component of any research process. Implementation of research findings into practice or policy is necessary for improving outcomes in the ...
Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis

Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, Adeyemo A, Williams TN, Atkinson SH (The Lancet, 2019-11)

Background: Vitamin D deficiency is associated with non-communicable and infectious diseases, but the vitamin D status of African populations is not well characterised. We aimed to estimate the prevalence of vitamin D ...
Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa

Tshilolo L, Tomlinson G, Williams TN, Santos B, Olupot-Olupot P, Lane A,Aygun B, Stuber SE, Latham TS, McGann PT, Ware RE; REACH Investigators (The New England Journal of Medicine, 2019-01)

Background: Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may ...
Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis

van Eijk AM, Zulaika G, Lenchner M, Mason L, Sivakami M, Nyothach E, Unger H, Laserson K, Phillips-Howard PA (The Lancet, 2019-07)

Background: Girls and women need effective, safe, and affordable menstrual products. Single-use products are regularly selected by agencies for resource-poor settings; the menstrual cup is a less known alternative. We ...
B-cell memory in malaria: Myths and realities

Pérez-Mazliah D, Ndungu FM, Aye R, Langhorne J (Wiley Online, 2019-11)

B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting ...
PEH 3105 Biostatistics for Epidemiological Studies

KEMRI Graduate School (2023-12)
Evaluation of Prescription Patterns of Helicobacter pylori Drugs in Out-Patient Department, Meru Teaching and Referral Hospital

Dr. Harshika Patel, Agneta Kwamboka, Dennis Magembe, Erickson Manyinsa, Kevine Ouma (2023)

BACKGROUND Helicobacter pylori infects up to half of the world’s population. Infection with Helicobacter pylori is a major contributing factor for gastric ulcers, gastric carcinoma, and extra gastric disease. The main aim ...
TPS 3103: Instrumental Methods of Analysis

KEMRI Graduate School (2023-12)
A Qualitative Study on Experiences and Perceptions of Screening for Enrolment in HIV Clinical Research among Volunteers in Kenya

Emily Nyariki, Joyce M. Olenja, Robert R. Lorway, Omu Anzala (2023)

INTRODUCTION Screening volunteers to determine their eligibility to enrol in clinical research is an important phase in clinical research. However, little is known about how volunteers view and experience this phase of ...
Evaluating Quality of Services in Community Differentiated Service Delivery Model. A case of Kakamega county

Winnie Sarah Owiti, Dr. Kezia Njoroge , Dr. Job Mapesa (2023)

BACKGROUND The provision of high-quality services is a prerequisite for the successful implementation of community-differentiated service delivery. The service quality influences the clients' satisfaction, perceived value ...
Factors Influencing Healthcare Access for Persons with Disabilities in Kakamega County, Kenya During COVID-19: A qualitative study

Stephene Osongo Maende, Dr. Pamela Godia, Dr. Islay Mactaggart, Dr. Calum Davey, Prof. Joyce Olenja (2023)

INTRODUCTION Access to healthcare for persons with disabilities is an indicator of the overall effectiveness of the healthcare system in terms of equity, accessibility and the right to health. This study explores factors ...
Effect of an Educational Intervention Program on Pregnant Women’s Ability to Cope with Childbirth Pain in Western Kenya

Mable Wanyonyi, Maximilla Wanzala, Mary Kipmerewo, Evans Raballah (2023)

INTRODUCTION Childbirth pain has remained a major challenge to women of child-bearing age over the years. Studies have shown that most women are not aware of the coping strategies to employ during childbirth. Severe ...
Utilization of Cervical Cancer Screening Services among Women Aged 18 to 59 Years in Laikipia East Sub-County, Kenya

Lily N. Njoroge, Godfrey H. Mudhune, George Otieno, Grace Wanjau, Alison Yoos (2023)

INTRODUCTION Cervical cancer, a preventable disease, continues to be the leading cause of death resulting from cancers in Kenya. Despite free cervical cancer screening services in all government hospitals in Laikipia ...
Prevalence and Determinants of Distress at the Start of Chemotherapy among Adult Cancer Patients in Two Tertiary Hospitals in Kenya

Francisca Mumbua Mwangangi., Drusilla Makworo, Joash Ronald Aluoch, Irene Mageto (2023)

BACKGROUND Chemotherapy is considered the cornerstone in the treatment of many cancers, but it also comes with its challenges. The distress experienced by patients at the commencement of chemotherapy is a critical aspect ...
Patient Factors Associated with Complementary and Alternative Medicine Use Among Cancer Patients at a County Referral Hospital, Kenya

Bravin George Etole, Sherry Oluchina, Bernard Wambua Mbithi (2023)

BACKGROUND Despite numerous global reports on the use of complementary and alternative medicine (CAM), no studies have been published regarding its use at Machakos Level 5 Hospital. Therefore, this study aims to identify ...
Factors Related to Sepsis in Critical Care Setting in Rwanda Selected Referral Hospital

Innocent Mwiseneza, Aurelia Nkomeje, Aline Umuhoza, Christian Mukwesi, Sylvestre Hategekimana (2023)

BACKGROUND Sepsis is described as potentially fatal organ failure induced by an unbalanced host response to infection. Annual estimates put the number of sepsis cases at over 19 million. The number of sepsis-related deaths ...
Sensorineural Hearing Loss among Hypertensive Patients Attending Cardiac Institute in Tanzania: A cross-sectional study

Enica Richard Massawe, Benjamin Mongi, Perfect Kishevo, Pedro Pallangyo (2023)

INTRODUCTION Hypertension is among non-communicable diseases worldwide and it has been associated with sensorineural hearing loss. Almost 1.39 billion people (1 out of 4 adults) have hypertension and this figure is expected ...

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