Recently added

KEMRI Institutional Repository: Recent submissions

  • Experiences along the HIV care continuum: perspectives of Kenyan adolescents and caregivers. 
    Luseno WK, Iritani B, Zietz S, Maman S, Mbai II, Otieno F, Ongili B, Hallfors DD. (African Journal of AIDS Research, 2017-09)
    To be effective, HIV programmes should be responsive to the unique needs of diverse groups of infected adolescents. We highlight a range of adolescent perspectives on HIV services, including those who acquired HIV ...
  • Neurodevelopment Disorders study group. Prevalence, risk factors, and neurobehavioral comorbidities of epilepsy in Kenyan children. 
    Kind CJ, Newton CRJC, Kariuki SM (Epilepsia Open., 2017-08)
    Objective: To investigate the prevalence, risk factors, clinical features, and neurobehavioral comorbidities of epilepsy and acute symptomatic seizures in schoolaged children in Kilifi, Kenya. Methods: Randomly selected ...
  • Examining levels, distribution and correlates of health insurance coverage in Kenya. 
    Kazungu JS, Barasa EW. (Trop Med Int Health., 2017-09)
    Objective: To examine the levels, inequalities and factors associated with health insurance coverage in Kenya. Methods: We analysed secondary data from the Kenya Demographic and Health Survey (KDHS) conducted in 2009 ...
  • Integrative microRNA and mRNA deep-sequencing expression profiling in endemic Burkitt lymphoma. 
    Oduor CI, Kaymaz Y, Chelimo K, Otieno JA, Ong'echa JM, Moormann AM, Bailey JA. (BMC Cancer., 2017-11)
    Background: Burkitt lymphoma (BL) is characterized by overexpression of the c-myc oncogene, which in the vast majority of cases is a consequence of an IGH/MYC translocation. While myc is the seminal event, BL is a complex ...
  • Performance of Celera RUO integrase resistance assay across multiple HIV-1 subtypes. 
    Wallis CL, Viana RV, Saravanan S, Silva de Jesus C, Zeh C, Halvas EK, Mellors JW. (Journal of Virological Methods, 2017-03)
    Background: HIV-1 sequence variation is a major obstacle to developing molecular based assays for multiple subtypes. This study sought to independently assess performance characteristics of the ViroSeq™ HIV-1 Integrase ...
  • Quantifying the intensity of permethrin insecticide resistance in Anopheles mosquitoes in western Kenya. 
    Omondi S, Mukabana WR, Ochomo E, Muchoki M, Kemei B, Mbogo C, Bayoh N. (Parasit Vectors, 2017-11)
    Background: The development and spread of resistance among local vectors to the major classes of insecticides used in Long-Lasting Insecticidal Nets (LLINs) and Indoor Residual Spraying (IRS) poses a major challenge to ...
  • Human vaccination against RH5 induces neutralizing antimalarial antibodies that inhibit RH5 invasion complex interactions. 
    Payne RO, Silk SE, Elias SC, Miura K, Diouf A, Galaway F, de Graaf H, Brendish NJ, Poulton ID, Griffiths OJ, Edwards NJ, Jin J, Labbé GM, Alanine DG, Siani L, Di Marco S, Roberts R, Green N, Berrie E, Ishizuka AS, Nielsen CM, Bardelli M, Partey FD, Ofori MF, Barfod L, Wambua J, Murungi LM, Osier FH, Biswas S, McCarthy JS, Minassian AM, Ashfield R, Viebig NK, Nugent FL, Douglas AD, Vekemans J, Wright GJ, Faust SN, Hill AV, Long CA, Lawrie AM, Draper SJ. (JCI Insight, 2017-11)
    The development of a highly effective vaccine remains a key strategic goal to aid the control and eventual eradication of Plasmodium falciparum malaria. In recent years, the reticulocyte-binding protein homolog 5 (RH5) ...
  • The development of an ivermectinbased attractive toxic sugar bait (ATSB) to target Anopheles arabiensis. 
    Tenywa FC, Kambagha A, Saddler A, Maia MF. (Malaria Journal, 2017-08)
    Background: An increasing number of countries in sub-Saharan Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in ...
  • Effect of transmission intensity on hotspots and micro-epidemiology of malaria in subSaharan Africa. 
    Mogeni P, Omedo I, Nyundo C, Kamau A, Noor A, Bejon P; Hotspot Group Authors. (BMC Med, 2017-06)
    Background: Malaria transmission intensity is heterogeneous, complicating the implementation of malaria control interventions. We provide a description of the spatial micro-epidemiology of symptomatic malaria and ...
  • Pastoral practices' for quality improvement in a Kenyan clinical network. 
    McGivern G, Nzinga J, English M. (Social Science & Medicine, 2017-12)
    We explain social and organisational processes influencing health professionals in a Kenyan clinical network to implement a form of quality improvement (QI) into clinical practice, using the concept of 'pastoral practices'. ...
  • Detecting Malaria Hotspots: A Comparison of Rapid Diagnostic Test, Microscopy, and Polymerase Chain Reaction. 
    Mogeni P, Williams TN, Omedo I, Kimani D, Ngoi JM, Mwacharo J, Morter R, Nyundo C, Wambua J, Nyangweso G, Kapulu M, Fegan G, Bejon P. (The Journal of Infectious Diseases, 2017-11)
    Background: Malaria control strategies need to respond to geographical hotspots of transmission. Detection of hotspots depends on the sensitivity of the diagnostic tool used. Methods: We conducted cross-sectional surveys ...
  • Mortality after Inpatient Treatment for Severe Pneumonia in Children: a Cohort Study. 
    Ngari MM, Fegan G, Mwangome MK, Ngama MJ, Mturi N, Scott JAG, Bauni E, Nokes DJ, Berkley JA. (Paediatric and Perinatal Epidemiology, 2017-05)
    Background: Although pneumonia is a leading cause of inpatient mortality, deaths may also occur after discharge from hospital. However, prior studies have been small, in selected groups or did not fully evaluate risk ...
  • Recentralization within decentralization: County hospital autonomy under devolution in Kenya. 
    Barasa EW, Manyara AM, Molyneux S, Tsofa B. (PLOS One, 2017-08)
    Background: In 2013, Kenya transitioned into a devolved system of government with a central government and 47 semi-autonomous county governments. In this paper, we report early experiences of devolution in the Kenyan ...
  • Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya. 
    Taitt CR, Leski TA, Erwin DP, Odundo EA, Kipkemoi NC, Ndonye JN, Kirera RK, Ombogo AN, Walson JL, Pavlinac PB, Hulseberg C, Vora GJ (PLOS One, 2017-06)
    We sought to determine the genetic and phenotypic antimicrobial resistance (AMR) profiles of commensal Klebsiella spp. circulating in Kenya by testing human stool isolates of 87 K. pneumoniae and three K. oxytoca collected ...
  • Malaria, malnutrition, and birthweight: A meta-analysis using individual participant data. 
    Cates JE, Unger HW, Briand V, Fievet N, Valea I, Tinto H, D'Alessandro U, Landis SH, Adu-Afarwuah S, Dewey KG, Ter Kuile FO, Desai M, Dellicour S, Ouma P, Gutman J, Oneko M, Slutsker L, Terlouw DJ, Kariuki S, Ayisi J, Madanitsa M, Mwapasa V, Ashorn P, Maleta K, Mueller I, Stanisic D, Schmiegelow C, Lusingu JPA, van Eijk AM, Bauserman M, Adair L, Cole SR, Westreich D, Meshnick S, Rogerson S. (PLOS Med, 2017-08)
    Background: Four studies previously indicated that the effect of malaria infection during pregnancy on the risk of low birthweight (LBW; <2,500 g) may depend upon maternal nutritional status. We investigated this dependence ...
  • Diagnostic criteria for severe acute malnutrition among infants aged under 6 mo. 
    Mwangome M, Ngari M, Fegan G, Mturi N, Shebe M, Bauni E, Berkley JA. (American Journal of Clinical Nutrition, 2017-06)
    Background: There is an increasing recognition of malnutrition among infants under 6 mo of age (U6M). Current diagnosis criteria use weight-for-length z scores (WLZs), but the 2006 WHO standards exclude infants shorter ...
  • The role of women's leadership and gender equity in leadership and health system strengthening. 
    Dhatt R, Theobald S, Buzuzi S, Ros B, Vong S, Muraya K, Molyneux S, Hawkins K, González-Beiras C, Ronsin K, Lichtenstein D, Wilkins K, Thompson K, Davis K, Jackson C. (Glob Health Epidemiol Genom., 2017-05)
    Gender equity is imperative to the attainment of healthy lives and wellbeing of all, and promoting gender equity in leadership in the health sector is an important part of this endeavour. This empirical research examines ...
  • Spatial accessibility to basic public health services in South Sudan. 
    Macharia PM, Ouma PO, Gogo EG, Snow RW, Noor AM. (Geospatial Health, 2017-05)
    At independence in 2011, South Sudan's health sector was almost non-existent. The first national health strategic plan aimed to achieve an integrated health facility network that would mean that 70% of the population ...
  • What influences feeding decisions for HIV-exposed infants in rural Kenya? 
    Nabwera HM, Jepkosgei J, Muraya KW, Hassan AS, Molyneux CS, Ali R, Prentice AM, Berkley JA, Mwangome MK (Int Breastfeed J., 2017-07)
    Background: Infant feeding in the context of human immunodeficiency virus (HIV) poses unique challenges to mothers and healthcare workers in balancing the perceived risks of HIV transmission and nutritional requirements. ...
  • Oxygen saturation ranges for healthy newborns within 24 hours at 1800 m 
    Morgan MC, Maina B, Waiyego M, Mutinda C, Aluvaala J, Maina M, English M. (Arch Dis Child Fetal Neonatal Ed., 2017-05)
    There are minimal data to define normal oxygen saturation (SpO2) levels for infants within the first 24 hours of life and even fewer data generalisable to the 7% of the global population that resides at an altitude of ...