Abstract:
The recently revised Sepsis-3 definitions were based on criteria that were derived and
validated in adult patient databases from high income countries. Both sepsis and septic
shock continue to account for a substantial proportion of mortality globally, especially
amongst children in low-and-middle income country settings. It is therefore urgent to
develop and validate standardized criteria for sepsis that can be applied to pediatric
populations in different settings, including in- and outside intensive care, both in highand low/middle- income countries. This will be a pre-requisite to evaluate the impact of
sepsis treatment strategies to improve clinical outcomes.