Recently added

KEMRI Research Papers: Recent submissions

  • Proceedings of an expert workshop on community agreement for gene drive research in Africa - Co-organised by KEMRI, PAMCA and Target Malaria 
    Thizy, Delphine; Toe, Lea Pare; Mbogo, Charles; Matoke-Muhia, Damaris; Alibu, Vincent Pius; Barnhill-Dilling, S. Kathleen; Chantler, Tracey; Chongwe, Gershom; Delborne, Jason; Kapiriri, Lydia; Nassonko Kavuma, Esther; Koloi-Keaikitse, Sethlomo; Kormos, Ana; Littler, Katherine; Lwetoijera, Dickson; Vargas de Moraes, Roberta; Mumba, Noni; Mutengu, Lilian; Mwichuli, Sylvia; Nabukenya, Silvia Elizabeth; Nakigudde, Janet; Ndebele, Paul; Ngara, Carolyne; Ochomo, Eric; Odiwuor Ondiek, Simon; Rivera, Stephany; Roberts, Aaron J.; Robinson, Benjamin; Sambakunsi, Rodrick; Saxena, Abha; Sykes, Naima; Tarimo, Brian B.; Tiffin, Nicki; Tountas, Karen H. (Gates Open Research, 2021-03)
    Gene drive research is progressing towards future field evaluation of modified mosquitoes for malaria control in sub-Saharan Africa. While many literature sources and guidance point to the inadequacy of individual informed ...
  • Applying a gender lens to understand pathways through care for acutely ill young children in Kenyan urban informal settlements 
    Muraya, Kui; Ogutu, Michael; Mwadhi, Mercy; Mikusa, Jennifer; Okinyi, Maureen; Magawi, Charity; Zakayo, Scholastica; Njeru, Rita; Haribondhu, Sarma; Uddin, Md Fakhar; Marsh, Vicki; Walson, Judd L.; Berkley, James; Molyneux, Sassy (BMC, 2021-01)
    Background In many African settings, gender strongly influences household treatment-seeking and decision-making for childhood illnesses. While mothers are often the primary engagers with health facilities, their independence ...
  • Development and Validation of a Sociodemographic and Behavioral Characteristics-Based Risk-Score Algorithm for Targeting HIV Testing Among Adults in Kenya 
    Muttai, Hellen; Guyah, Bernard; Musingila, Paul; Achia, Thomas; Miruka, Fredrick; Wanjohi, Stella; Dande, Caroline; Musee, Polycarp; Lugalia, Fillet; Onyango, Dickens; Kinywa, Eunice; Okomo, Gordon; Moth, Iscah; Omondi, Samuel; Ayieko, Caren; Nganga, Lucy; Joseph, Rachael H.; Zielinski-Gutierrez, Emily (Springer Link, 2021-02)
    To inform targeted HIV testing, we developed and externally validated a risk-score algorithm that incorporated behavioral characteristics. Outpatient data from five health facilities in western Kenya, comprising 19,458 ...
  • Integrating epidemiological and genetic data with different sampling intensities into a dynamic model of respiratory syncytial virus transmission 
    Kombe, Ivy K.; Agoti, Charles N.; Munywoki, Patrick K.; Baguelin, Marc; Nokes, D. James; Medley, Graham F. (PubMed, 2021-01)
    espiratory syncytial virus (RSV) is responsible for a significant burden of severe acute lower respiratory tract illness in children under 5 years old; particularly infants. Prior to rolling out any vaccination program, ...
  • A review of the frequencies of Plasmodium falciparum Kelch 13 artemisinin resistance mutations in Africa 
    Ndwiga, Leonard; Kimenyi, Kelvin M.; Wamae, Kevin; Osoti, Victor; Akinyi, Mercy; Omedo, Irene; Ishengoma, Deus S.; Duah-Quashie, Nancy; Andagalu, Ben; Ghansah, Anita; Amambua-Ngwa, Alfred; Tukwasibwe, Stephen; Tessema, Sofonias K.; Karema, Corine; Djimde, Abdoulaye A.; Dondorp, Arjen M.; Raman, Jaishree; Snow, Robert W.; Bejon, Philip; Ochola-Oyier, Lynette Isabella (Elsevier, 2021-08)
    Artemisinin resistance (AR) emerged in South East Asia 13 years ago and the identification of the resistance conferring molecular marker, Plasmodium falciparum Kelch 13 (Pfk13), 7 years ago has provided an invaluable tool ...
  • Health system responsiveness: a systematic evidence mapping review of the global literature 
    Khan, Gadija; Kagwanja, Nancy; Whyle, Eleanor; Gilson, Lucy; Molyneux, Sassy; Schaay, Nikki; Tsofa, Benjamin; Barasa, Edwine; Olivier, Jill (BMC, 2021-05)
    Background The World Health Organisation framed responsiveness, fair financing and equity as intrinsic goals of health systems. However, of the three, responsiveness received significantly less attention. Responsiveness ...
  • Mortality during and following hospital admission among school-aged children: a cohort study 
    Ngari, Moses M.; Obiero, Christina; Mwangome, Martha K.; Nyaguara, Amek (Wellcome Open Research, 2021-01)
    Background: Far less is known about the reasons for hospitalization or mortality during and after hospitalization among school-aged children than among under-fives in low- and middle-income countries. This study aimed to ...
  • Using cross-species vaccination approaches to counter emerging infectious diseases 
    Warimwe, George M.; Francis, Michael J.; Bowden, Thomas A.; Thumbi, Samuel M.; Charleston, Bryan (Nature, 2021-12)
    Since the initial use of vaccination in the eighteenth century, our understanding of human and animal immunology has greatly advanced and a wide range of vaccine technologies and delivery systems have been developed. The ...
  • How urban 'informality' can inform response to COVID-19: a research agenda for the future 
    Onditi, Francis; Nyadera, Israel Nyaburi; Obimbo, Moses Madadi; Muchina, Samson Kinyanjui (Springer Link, 2021-01)
    In the era of increasingly defined ontological insecurity and uncertainty driven by the ravages of COVID-19, urban informal settlement has emerged as a source of resilience. Indeed, the effects of a pandemic transcends its ...
  • Urban Ecology of Arboviral Mosquito Vectors Along the Kenyan Coast 
    Karisa, Jonathan; Muriu, Simon; Omuoyo, Donwilliams; Karia, Boniface; Ngari, Moses; Nyamwaya, Doris; Rono, Martin; Warimwe, George; Mwangangi, Joseph; Mbogo, Charles M. (Oxford Academic, 2021-01)
    The purpose of this study was to determine the ecology of the common arboviral mosquito vectors in Mombasa, Kilifi and Malindi urban areas of coastal Kenya. Mosquito larvae were collected using standard dippers and pipettes. ...
  • Malaria micro-stratification using routine surveillance data in Western Kenya 
    Alegana, Victor A.; Suiyanka, Laurissa; Macharia, Peter M.; Muchangi, Grace Ikahu; Snow, Robert W. (BMC, 2021-01)
    Background There is an increasing need for finer spatial resolution data on malaria risk to provide micro-stratification to guide sub-national strategic plans. Here, spatial-statistical techniques are used to exploit ...
  • First do no harm: practitioners' ability to 'diagnose' system weaknesses and improve safety is a critical initial step in improving care quality 
    English, Mike; Ogola, Muthoni; Aluvaala, Jalemba; Gicheha, Edith; Irimu, Grace; McKnight, Jacob; Vincent, Charles A. (BMJ Journals, 2021-04)
    Healthcare systems across the world and especially those in low-resource settings (LRS) are under pressure and one of the first priorities must be to prevent any harm done while trying to deliver care. Health care workers, ...
  • Detection and Characterization of Salmonella enterica Serotypes by Simple PCR Technologies 
    Kariuki, Samuel; Kiiru, John (Springer Link, 2020-09)
    Polymerase chain reaction (PCR) is a molecular-based technology that has revolutionized diagnostics and characterization of pathogens, and thus affecting how we understand disease landscape. This technology has been found ...
  • Tools for measuring medical internship experience: a scoping review 
    Zhao, Yingxi; Musitia, Peris; Boga, Mwanamvua; Gathara, David; Nicodemo, Catia; English, Mike (BMC, 2021-01)
    Background: Appropriate and well-resourced medical internship training is important to ensure psychological health and well-being of doctors in training and also to recruit and retain these doctors. However, most reviews ...
  • Clinical features to distinguish meningitis among young infants at a rural Kenyan hospital 
    Obiero, Christina W.; Mturi, Neema; Mwarumba, Salim; Ngari, Moses; Newton, Charles; Hensbroek, Michael Boele van; Berkley, James Alexander (BMJ Journals, 2021-02)
    Background: Detection of meningitis is essential to optimise the duration and choice of antimicrobial agents to limit mortality and sequelae. In low and middle-income countries most health facilities lack laboratory capacity ...
  • Designing paper-based records to improve the quality of nursing documentation in hospitals: A scoping review 
    Muinga, Naomi; Abejirinde, Ibukun-Oluwa Omolade; Paton, Chris; Mike, English; Zweekhorst, Marjolein (Wiley Online, 2021-01)
    Background: Inpatient nursing documentation facilitates multi-disciplinary team care and tracking of patient progress. In both high- and low- and middle-income settings, it is largely paper-based and may be used as a ...
  • Immune responses to malaria pre-erythrocytic stages: Implications for vaccine development 
    Abuga, Kelvin Mokaya; Jones-Warner, William; Hafalla, Julius Clemence R. (Wiley Online, 2021-02)
    Radiation-attenuated sporozoites induce sterilizing immunity and remain the 'gold standard' for malaria vaccine development. Despite practical challenges in translating these whole sporozoite vaccines to large-scale ...
  • Respiratory syncytial virus seasonality in three epidemiological zones of Kenya 
    Rose, Erica Billig; Nyawanda, Bryan O.; Munywoki, Patrick K.; Murunga, Nickson; Bigogo, Godfrey M.; Otieno, Nancy A.; Onyango, Clayton; Chaves, Sandra S.; Verani, Jennifer R.; Emukule, Gideon O.; Widdowson, Marc-Alain; Nokes, D. James; Gerber, Susan I.; Langley, Gayle E. (Wiley Online, 2021-03)
    Understanding respiratory syncytial virus (RSV) circulation patterns is necessary to guide the timing of limited-duration interventions such as vaccines. We describe RSV circulation over multiple seasons in three distinct ...
  • Antiplasmodial and antileishmanial flavonoids from Mundulea sericea 
    Chepkirui, Carolyne; Ochieng, Purity J.; Sarkar, Biswajyoti; Hussain, Aabid; Pal, Chiranjib; Yang, Li Jun; Coghi, Paolo; Akala, Hosea; Derese, Solomon; Ndakala, Albert; Heydenreich, Matthias; Wong, Vincent K. W.; Erdélyi, Máté; Yenesew, Abiy (Science Direct, 2021-03)
    Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using ...
  • Seroprevalence of anti-SARS-CoV-2 IgG antibodies in Kenyan blood donors 
    Uyoga, Sophie; Adetifa, Ifedayo; Karanja, Henry; Nyagwange, James; Tuju, James; Wanjiku, Perpetual; Aman, Rashid; Tsofa, Benjamin; Mwangangi, Mercy; Amoth, Patrick; Kadondi, Kasera; Ng'ang'a, Wangari; Rombo, Charles; Yegon, Christine; Kithi, Khamisi; Odhiambo, Elizabeth; Rotich, Thomas; Orgut, Irene; Kihara, Sammy; Otiende, Mark; Bottomley, Christian; Mupe, Zonia; Kagucia, Eunice; Gallagher, Katherine; Etyang, Anthony; Voller, Shirine; Gitonga, John; Mugo, Daisy; Agoti, Charles; Otieno, Edward; Ndwiga, Leonard; Lambe, Teresa; Wright, Daniel; Barasa, Edwine; Bejon, Philip; Ochola-Oyier, Lynette; Agweyu, Ambrose; G Scott, Anthony; Warimwe, George (2021-01-01)
    The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Africa is poorly described. The first case of SARS-CoV-2 in Kenya was reported on 12 March 2020, and an overwhelming number of cases and deaths ...

Search DSpace


Advanced Search

Browse

My Account