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KEMRI Research Papers: Recent submissions

  • Health Risk Behaviour among Adolescents Living with HIV in Sub-Saharan Africa: A Systematic Review and Meta-Analysis. 
    Ssewanyana D, Mwangala PN, van Baar A, Newton CR, Abubakar A. (BioMed Research International, 2018-01)
    The burden of health risk behaviour (HRB) among adolescents living with HIV (ALWHIV) in sub-Saharan Africa (SSA) is currently unknown. A systematic search for publications on HRB among ALWHIV in SSA was conducted in ...
  • What Is Resilience and How Can It Be Nurtured? A Systematic Review of Empirical Literature on Organizational Resilience. 
    Barasa E, Mbau R, Gilson L. (International Journal of Health Policy and Management, 2018-06)
    Background: Recent health system shocks such as the Ebola outbreak of 2014-2016 and the global financial crisis of 2008 have generated global health interest in the concept of resilience. The concept is however not new, ...
  • Suicide in a rural area of coastal Kenya. 
    Bitta MA, Bakolis I, Kariuki SM, Nyutu G, Mochama G, Thornicroft G, Newton CRJC. (BMC psychiatry, 2018-08)
    Background: Suicide accounts for approximately 1.4% of deaths globally and is the 15th leading cause of death overall. There are no reliable data on the epidemiology of completed suicide in rural areas of many developing ...
  • Expectations for nursing care in newborn units in Kenya: moving from implicit to explicit standards. 
    Murphy GAV, Omondi GB, Gathara D, Abuya N, Mwachiro J, Kuria R, TallamKimaiyo E, English M. (BMJ Global Health, 2018-03)
    Neonatal mortality currently accounts for 45% of all child mortality in Kenya, standing at 22 per 1000 live births. Access to basic but high quality inpatient neonatal services for small and sick newborns will be key in ...
  • What characteristics of provider payment mechanisms influence health care providers' behaviour? 
    Kazungu JS, Barasa EW, Obadha M, Chuma J. (International journal of health planning and management, 2018-10)
    Background Provider payment mechanisms (PPMs) create incentives or signals that influence the behaviour of health care providers. Understanding the characteristics of PPMs that influence health care providers' behaviour ...
  • The NeuroDev Study: Phenotypic and Genetic Characterization of Neurodevelopmental Disorders in Kenya and South Africa 
    de Menil V, Hoogenhout M, Kipkemoi P, Kamuya D, Eastman E, Galvin A, Mwangasha K, de Vries J, Kariuki SM, Murugasen S, Mwangi P, Singh I, Stein DJ, Abubakar A, Newton CR, Donald KA, Robinson E (Cell Press, 2019-01)
    he NeuroDev study will deeply phenotype cognition, behavior, dysmorphias, and neuromedical traits on an expected cohort of 5,600 Africans (1,800 child cases, 1,800 child controls, and 1,900 parents) and will collect whole ...
  • Mosquito microevolution drives Plasmodium falciparum dynamics 
    Gildenhard M, Rono EK, Diarra A, Boissière A, Bascunan P, Carrillo- Bustamante P, Camara D, Krüger H, Mariko M, Mariko R, Mireji P, Nsango SE, Pompon J, Reis Y, Rono MK, Seda PB, Thailayil J, Traorè A, Yapto CV, Awono- Ambene P, Dabiré RK, Diabaté A, Masiga D, Catteruccia F, Morlais I, Diallo M, Sangare D, Levashina EA (Nature, 2019-06)
    Malaria, a major cause of child mortality in Africa, is engendered by Plasmodium parasites that are transmitted by anopheline mosquitoes. Fitness of Plasmodium parasites is closely linked to the ecology and evolution of ...
  • Implementation of Good Clinical Laboratory Practice in an Immunology Basic Research Laboratory: The KEMRI-Wellcome Trust Research Laboratories Experience 
    Gumba H, Musyoki J, Mosobo M, Lowe B (American Journal of Clinical Pathology, 2019-02)
    Objectives: Good Clinical Laboratory Practice (GCLP) is a standard that ensures quality and reliability of research data by adopting the principles of Good Laboratory Practice and Good Clinical Practice. Even though ...
  • Corrigendum: Sepsis: Changing Definitions, Unchanging Treatment 
    Obonyo NG, Schlapbach LJ, Fraser JF (Frontiers, 2020-01)
    The recently revised Sepsis-3 definitions were based on criteria that were derived and validated in adult patient databases from high income countries. Both sepsis and septic shock continue to account for a substantial ...
  • Tackling the triple threats of childhood malnutrition 
    Mwangome M, Prentice AM (BMC Medicine, 2019-11)
    The term 'double burden of malnutrition' is usually interpreted in terms of the physical status of children: stunted and wasted children on the one hand and overweight/obese children on the other. There is a third category ...
  • Implementing a quality management system using good clinical laboratory practice guidelines at KEMRI-CMR to support medical research 
    Gumba H, Waichungo J, Lowe B, Mwanzu A, Musyimi R, Thitiri J, Tigoi C, Kamui M, Berkley JA, Ngetich R, Kavai S, Kariuki S (Wellcome Open Research, 2019-06)
    Background: Good Clinical Laboratory Practice (GCLP) is a standard that helps ensure the quality and reliability of research data through principles of Good Laboratory Practice (GLP) and Good Clinical Practice (GCP). The ...
  • A reduced-carbohydrate and lactose-free formulation for stabilization among hospitalized children with severe acute malnutrition: A double-blind, randomized controlled trial 
    Bandsma RHJ, Voskuijl W, Chimwezi E, Fegan G, Briend A, Thitiri J, Ngari M, Mwalekwa L, Bandika V, Ali R, Hamid F, Owor B, Mturi N, Potani I, Allubha B, Muller Kobold AC, Bartels RH, Versloot CJ, Feenstra M, van den Brink DA, van Rheenen PF, Kerac M, Bourdon C, Berkley JA (PLOS One Journals, 2019-02)
    Background: Children with medically complicated severe acute malnutrition (SAM) have high risk of inpatient mortality. Diarrhea, carbohydrate malabsorption, and refeeding syndrome may contribute to early mortality and ...
  • Research Dissemination Strategies Used by Kenya Medical Research Institute Scientists 
    Kariuki JN, Kaburi J, Musuva R, Njomo DW, Night D, Wandera C, Wodera J, Mwinzi PN (The East African Health Research Journal, 2019-07)
    Background: Dissemination of research findings is acknowledged as an important component of any research process. Implementation of research findings into practice or policy is necessary for improving outcomes in the ...
  • Prevalence of vitamin D deficiency in Africa: a systematic review and meta-analysis 
    Mogire RM, Mutua A, Kimita W, Kamau A, Bejon P, Pettifor JM, Adeyemo A, Williams TN, Atkinson SH (The Lancet, 2019-11)
    Background: Vitamin D deficiency is associated with non-communicable and infectious diseases, but the vitamin D status of African populations is not well characterised. We aimed to estimate the prevalence of vitamin D ...
  • Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa 
    Tshilolo L, Tomlinson G, Williams TN, Santos B, Olupot-Olupot P, Lane A,Aygun B, Stuber SE, Latham TS, McGann PT, Ware RE; REACH Investigators (The New England Journal of Medicine, 2019-01)
    Background: Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. Coexisting conditions such as malnutrition and malaria may ...
  • Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis 
    van Eijk AM, Zulaika G, Lenchner M, Mason L, Sivakami M, Nyothach E, Unger H, Laserson K, Phillips-Howard PA (The Lancet, 2019-07)
    Background: Girls and women need effective, safe, and affordable menstrual products. Single-use products are regularly selected by agencies for resource-poor settings; the menstrual cup is a less known alternative. We ...
  • B-cell memory in malaria: Myths and realities 
    Pérez-Mazliah D, Ndungu FM, Aye R, Langhorne J (Wiley Online, 2019-11)
    B-cell and antibody responses to Plasmodium spp., the parasite that causes malaria, are critical for control of parasitemia and associated immunopathology. Antibodies also provide protection to reinfection. Long-lasting ...
  • Keeping people with epilepsy safe during the COVID-19 pandemic 
    French JA, Brodie MJ, Caraballo R, Devinsky O, Ding D, Jehi L, Jette N, Kanner A, Modi AC, Newton CR, Patel AA, Pennell PB, Perucca E, Sander JW, Scheffer IE, Singh G, Williams E, Wilmshurst J, Cross JH (Neurology Journals, 2020-06)
    Objectives To provide information on the effect of the coronavirus disease of 2019 (COVID-19) pandemic on people with epilepsy and provide consensus recommendations on how to provide the best possible care for people with ...
  • Disrupting gender norms in health systems: making the case for change 
    Hay K, McDougal L, Percival V, Henry S, Klugman J, Wurie H, Raven J, Shabalala F, Fielding-Miller R, Dey A, Dehingia N, Morgan R, Atmavilas Y, Saggurti N, Yore J, Blokhina E, Huque R, Barasa E, Bhan N, Kharel C, Silverman JG, Raj A; Gender Equality, Norms, and Health Steering Committee (The Lancet, 2019-06)
    Restrictive gender norms and gender inequalities are replicated and reinforced in health systems, contributing to gender inequalities in health. In this Series paper, we explore how to address all three through recognition ...
  • Rift Valley fever: biology and epidemiology 
    Wright D, Kortekaas J, Bowden TA, Warimwe GM (Journal of General Virology, 2019-08)
    Rift Valley fever (RVF) is a mosquito-borne viral zoonosis that was first discovered in Kenya in 1930 and is now endemic throughout multiple African countries and the Arabian Peninsula. RVF virus primarily infects domestic ...

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