KEMRI Research Papers: Recent submissions

Now showing items 101-120 of 421

Association between Rift Valley fever virus seroprevalences in livestock and humans and their respective intra-cluster correlation coefficients, Tana River County, Kenya.

Bett B, Lindahl J, Sang R, Wainaina M, Kairu-Wanyoike S, Bukachi S, Njeru I, Karanja J, Ontiri E, Kariuki Njenga M, Wright D, Warimwe GM, Grace D. (Epidemiology and infection., 2018-12)

We implemented a cross-sectional study in Tana River County, Kenya, a Rift Valley fever (RVF)-endemic area, to quantify the strength of association between RVF virus (RVFv) seroprevalences in livestock and humans, and their ...
Whole genome analysis of local Kenyan and global sequences unravels the epidemiological andmolecular evolutionary dynamics of RSV genotype ON1 strains.

Otieno JR, Kamau EM, Oketch JW, Ngoi JM, Gichuki AM, Binter Š, Otieno GP, Ngama M, Agoti CN, Cane PA, Kellam P, Cotten M, Lemey P, Nokes DJ. (Virus Evol, 2018-09)

The respiratory syncytial virus (RSV) group A variant with the 72-nucleotide duplication in the G gene, genotype ON1, was first detected in Kilifi in 2012 and has almost completely replaced circulating genotype GA2 strains. ...
Impact of Mothers' Schistosomiasis Status During Gestation on Children's IgG Antibody Responses to Routine Vaccines 2 Years Later and Anti-Schistosome and Anti-Malarial Responses by Neonates in Western Kenya.

Ondigo BN, Muok EMO, Oguso JK, Njenga SM, Kanyi HM, Ndombi EM, Priest JW, Kittur N, Secor WE, Karanja DMS, Colley DG. (Front Immunol, 2018-06)

The potential consequences of parasitic infections on a person's immune responsiveness to unrelated antigens are often conjectured upon in relationship to allergic responses and autoimmune diseases. These considerations ...
Comparing the performance of circulating cathodic antigen and Kato-Katz techniques in evaluating Schistosomamansoni infection in areas with low prevalence in selected counties of Kenya: a cross-sectional study.

Okoyo C, Simiyu E, Njenga SM, Mwandawiro C. (BMC Public Health, 2018-04)

Background: Kato-Katz technique has been the mainstay test in Schistosoma mansoni diagnosis in endemic areas. However, recent studies have documented its poor sensitivity in evaluating Schistosoma mansoni infection especially ...
Malaria chemoprevention with monthly dihydroartemisinin-piperaquine for the postdischarge management of severe anaemia in children aged less than 5 years in Uganda and Kenya: study protocol for a multi-centre, two-arm, randomised, placebo-controlled, superiority trial.

Kwambai TK, Dhabangi A, Idro R, Opoka R, Kariuki S, Samuels AM, Desai M, van Hensbroek MB, John CC, Robberstad B, Wang D, Phiri K, Ter Kuile FO. (Trials, 2018-11)

Background: Children hospitalised with severe anaemia in malaria endemic areas in Africa are at high risk of readmission or death within 6 months post-discharge. Currently, no strategy specifically addresses this period. ...
Strengthening intrapartum and immediate newborn care to reduce morbidity and mortality of preterm infants born in health facilities in Migori County, Kenya and Busoga Region, Uganda: a study protocol for a randomized controlled trial.

Otieno P, Waiswa P, Butrick E, Namazzi G, Achola K, Santos N, Keating R, Lester F, Walker D. (Trials, 2018-06)

Background: Preterm birth (birth before 37 weeks of gestation) and its complications are the leading contributors to neonatal and under-5 mortality. The majority of neonatal deaths in Kenya and Uganda occur during the ...
Maximizing adherence and retention for women living with HIV and their infants in Kenya (MOTIVATE! study): study protocol for a randomized controlled trial.

Odeny TA, Onono M, Owuor K, Helova A, Wanga I, Bukusi EA, Turan JM, Abuogi LL. (Trials, 2018-01)

Background: Successful completion and retention throughout the multi-step cascade of prevention of mother-to-child HIV transmission (PMTCT) remains difficult to achieve. The Mother and Infant Visit Adherence and Treatment ...
Ethical considerations in Controlled Human Malaria Infection studies in low resource settings: Experiences and perceptions of study participants in a malaria Challenge study in Kenya.

Njue M, Njuguna P, Kapulu MC, Sanga G, Bejon P, Marsh V, Molyneux S, KamuyaD. (Wellcome Open Research, 2018-10)

Background: The range and amount of volunteer infection studies, known as Controlled Human Infection Model (CHMI) studies, in Low-Middle Income Countries (LMICs) is increasing with rapid technological advancement, ...
Neonatal nasogastric tube feeding in a low-resource African setting using ergonomics methods to explore quality and safety issues in task sharing.

Omondi GB, Serem G, Abuya N, Gathara D, Stanton NA, Agedo D, English M, Murphy GAV. (BMC Nursing, 2018)

Background: Sharing tasks with lower cadre workers may help ease the burden of work on the constrained nursing workforce in low- and middle-income countries but the quality and safety issues associated with shifting tasks ...
High levels of viral suppression among East African HIV-infected women and men in serodiscordant partnerships initiating antiretroviral therapy with high CD4 counts and during pregnancy

Mujugira A, Baeten J, Kidoguchi L, Haberer J, Celum C, Donnell D, Ngure K,Bukusi E, Mugo N, Asiimwe S, Odoyo J, Tindimwebwa E, Bulya N, Katabira E, Heffron R. (AIDS Research and Human Retroviruses, 2018-02)

Background: People who are asymptomatic and feel healthy, including pregnant women, may be less motivated to initiate ART or achieve high adherence. We assessed whether ART initiation, and viral suppression 6, 12 and ...
Health Services that Deliver for Newborns Expert Group. Effective coverage of essential inpatient care for small and sick newborns in a high mortality urban setting: a crosssectional study in Nairobi City County, Kenya.

Murphy GAV, Gathara D, Mwachiro J, Abuya N, Aluvaala J, English M (BMC Med, 2018)

Background: Effective coverage requires that those in need can access skilled care supported by adequate resources. There are, however, few studies of effective coverage of facility-based neonatal care in low-income ...
Uptake of skilled attendance along the continuum of care in rural Western Kenya: selected analysis from Global Health initiative survey-2012.

Mwangi W, Gachuno O, Desai M, Obor D, Were V, Odhiambo F, Nyaguara A, Laserson KF. (BMC Pregnancy Childbirth, 2018-05)

Background: Examining skilled attendance throughout pregnancy, delivery and immediate postnatal period is proxy indicator on the progress towards reduction of maternal and neonatal mortality in developing countries. Methods: ...
The influence of maternal psychosocial circumstances and physical environment on the risk of severe wasting in rural Gambian infants: a mixed methods approach.

Nabwera HM, Moore SE, Mwangome MK, Molyneux SC, Darboe MK, CamaraTrawally N, Sonko B, Darboe A, Singhateh S, Fulford AJ, Prentice AM. (BMC Public Health, 2018-01)

Background: Severe wasting affects 16 million under 5's and carries an immediate risk of death. Prevalence remains unacceptably high in sub-Saharan Africa and early infancy is a high-risk period. We aimed to explore risk ...
Every day they keep adding new tools but they don't take any away": Producing indicators for intermittent preventive treatment for malaria in pregnancy (IPTp) from routine data in Kenya.

Okello G, Gerrets R, Zakayo S, Molyneux S, Jones C. (PLOS One, 2018-01)

Background: Intermittent preventive treatment for malaria in pregnancy (IPTp) is part of a multi-pronged strategy aimed at preventing malaria in pregnancy in areas of moderate to high transmission in sub-Saharan Africa. ...
Evaluating the impact of the DREAMS partnership to reduce HIV incidence among adolescent girls and young women in four settings: a study protocol.

Birdthistle I, Schaffnit SB, Kwaro D, Shahmanesh M, Ziraba A, Kabiru CW, PhillipsHoward P, Chimbindi N, Ondeng'e K, Gourlay A, Cowan FM, Hargreaves JR, Hensen B, Chiyaka T, Glynn JR, Floyd S. (BMC Public Health, 2018-07)

Background: HIV risk remains unacceptably high among adolescent girls and young women (AGYW) in southern and eastern Africa, reflecting structural and social inequities that drive new infections. In 2015, PEPFAR (the ...
Population mobility associated with higher risk sexual behaviour in eastern African communities participating in a Universal Testing and Treatment trial.

Camlin CS, Akullian A, Neilands TB, Getahun M, Eyul P, Maeri I, Ssali S, Geng E, Gandhi M, Cohen CR, Kamya MR, Odeny T, Bukusi EA, Charlebois ED. (Journal of the International AIDS Society., 2018-07)

Introduction: There are significant knowledge gaps concerning complex forms of mobility emergent in sub-Saharan Africa, their relationship to sexual behaviours, HIV transmission, and how sex modifies these associations. ...
Association between internal migration and epidemic dynamics: an analysis of cause-specific mortality in Kenya and South Africa using health and demographic surveillance data.

Ginsburg C, Bocquier P, Béguy D, Afolabi S, Kahn K, Obor D, Tanser F,Tomita A, Wamukoya M, Collinson MA. (BMC Public Health, 2018-07)

Background: Many low- and middle-income countries are facing a double burden of disease with persisting high levels of infectious disease, and an increasing prevalence of non-communicable disease (NCD). Within these ...
HIV care engagement and ART adherence among Kenyan gay, bisexual, and other men who have sex with men: a multi-level model informed by qualitative research.

Graham SM, Micheni M, Secor A, van der Elst EM, Kombo B, Operario D, Amico KR, Sanders EJ, Simoni JM. (AIDS Care, 2018-08)

Gay, bisexual, and other men who have sex with men (GBMSM) are highly stigmatized and male-male sex is often criminalized in sub-Saharan Africa, impeding access to quality care for sexual health, HIV prevention, and ...
Knowledge and Adherence to the National Guidelines for Malaria Diagnosis in Pregnancy among Health-Care Providers and Drug-Outlet Dispensers in Rural Western Kenya.

Riley C, Dellicour S, Ouma P, Kioko U, Omar A, Kariuki S, Ng'ang'a Z, DesaiM, Buff AM, Gutman JR. (American journal of tropical medicine and hygiene, 2018-05)

Prompt diagnosis and effective treatment of acute malaria in pregnancy (MiP) is important for the mother and fetus; data on health-care provider adherence to diagnostic guidelines in pregnancy are limited. From September ...
Health worker knowledge of Integrated Disease Surveillance and Response standard case definitions: a crosssectional survey at rural health facilities in Kenya.

Toda M, Zurovac D, Njeru I, Kareko D, Mwau M, Morita K. (BMC Public Health, 2018-01)

Background: The correct knowledge of standard case definition is necessary for frontline health workers to diagnose suspected diseases across Africa. However, surveillance evaluations commonly assume this prerequisite. ...

Now showing items 101-120 of 421

Search DSpace

Advanced Search

Browse

All of DSpace
This Collection
- By Issue Date
- Authors
- Titles
- Subjects

Recently added

KEMRI Research Papers: Recent submissions

Search DSpace

Browse

All of DSpace

This Collection

My Account