Browsing KEMRI Research Papers by Title

Now showing items 1-20 of 421

Accountability mechanisms and the value of relationships: experiences of front- line managers at subnational level in Kenya and South Africa.

Nxumalo N, Gilson L, Goudge J, Tsofa B, Cleary S, Barasa E, Molyneux S. (BMJ Global Health, 2018-07)

Resource constraints, value for money debates and concerns about provider behaviour have placed accountability 'front and centre stage' in health system improvement initiatives and policy prescriptions. There are a myriad ...
An adapted instrument to assess informed consent comprehension among youth and parents in rural western Kenya: a validation study

Afolabi MO, Rennie S, Hallfors DD, Kline T, Zeitz S, Odongo FS, Amek NO, Luseno WK. (BMJ Open, 2018-07)

Objective: To adapt and validate a questionnaire originally developed in a research setting for assessment of comprehension of consent information in a different cultural and linguistic research setting. Design: The ...
Addressing barriers of community participation and access to mass drug administration for lymphatic filariasis elimination in Coastal Kenya using a participatory approach.

Njomo DW, Kibe LW, Kimani BW, Okoyo C, Omondi WP, Sultani HM. (PLoS neglected tropical diseases., 2020-09)

Since the prioritization of Lymphatic Filariasis (LF) elimination in 1997, progress has been made in reducing disease transmission and burden. Validation of elimination through Transmission Assessment Surveys (TAS) in ...
Addressing power asymmetries in global health: Imperatives in the wake of the COVID-19 pandemic.

Abimbola, S; Asthana, S; Montenegro, C; Guinto, R R; Jumbam, DT; Louskieter, L; Kabubei, KM; Munshi, S; Muraya, K; Okumu, F; Saha, S; Saluja, D; Pai, M (PLOS Med, 2021-04)
Adolescent perceptions about participating in HIV-related research studies.

Simons-Rudolph, AP; Iritani, BJ; Odongo, FS; Rennie, S; Gilbertson, A; Kwaro, D; Luseno, WK (Oxford : Elsevier Ltd, 2020-09)

The rising incidence of infection among youth in sub-Saharan Africa makes HIV-related research among younger people a top priority. There remains, however, a lack of consistent and unambiguous ethical principles and guidance ...
Adoption of routine virologic testing and predictors of virologic failure among HIV-infected children on antiretroviral treatment in western Kenya.

Kadima J, Patterson E, Mburu M, Blat C, Nyanduko M, Bukusi EA, Cohen C, Oyaro P, Abuogi L. (PLOS One, 2018-11)

Background: Access to routine virologic monitoring, critical to ensuring treatment success, remains limited in low- and middle-income countries. We report on implementation of routine viral load (VL) monitoring and risk ...
Airway response to respiratory syncytial virus has incidental antibacterial effects

Sande CJ, Njunge JM, Mwongeli Ngoi J, Mutunga MN, Chege T, Gicheru ET, Gardiner EM, Gwela A, Green CA, Drysdale SB, Berkley JA, Nokes DJ, Pollard AJ (Nature, 2019-05)

RSV infection is typically associated with secondary bacterial infection. We hypothesise that the local airway immune response to RSV has incidental antibacterial effects. Using coordinated proteomics and metagenomics ...
Always leave the audience wanting more: An entertaining approach to stimulate engagement with health research among publics in coastal Kenya through 'Magnet Theatre'.

Sanga, G; Jao, I; Mumba, N; Mwalukore, S; Kamuya, D; Davies, A (Wellcome Open Research, 2021-01)

Background: Magnet Theatre (MT), a form of participatory community theatre, is one of several public engagement approaches used to facilitate engagement between KEMRI-Wellcome Trust Research Programme (KWTRP) researchers ...
Anthropometric measures and their association with risk factors for cardio-metabolic diseases in Kenyan adults.

Lajeunesse-Trempe F, Dufour R, du Souich P, Paquette M, Kaduka LU, Christensen DL. (Annals of Human Biology, 2019-01)

Background: The prevalence of cardio-metabolic diseases (CMD) is drastically increasing worldwide. Anthropometric measures of fat accumulation are correlated with CMD and Metabolic Syndrome (MS), but few studies have ...
Antibiotic use in Kenyan public hospitals: Prevalence, appropriateness and link to guideline availability

Maina, M; Mwaniki, P; Odira, E; Kiko, N; McKnight, J; Schultsz, C; English, M (International journal of infectious diseases, 2020-10)

Objective: To examine prescription patterns and explore to what extent guidelines are available and how they might influence treatment appropriateness among hospitalised patients in Kenyan hospitals. Methods: Data on ...
Antibiotics and activity spaces: protocol of an exploratory study of behaviour, marginalisation and knowledge diffusion.

Haenssgen MJ, Charoenboon N, Zanello G, Mayxay M, Reed-Tsochas F, Jones COH,Kosaikanont R, Praphattong P, Manohan P, Lubell Y, Newton PN, Keomany S, Wertheim HFL, Lienert J, Xayavong T, Warapikuptanun P, Khine Zaw Y, U-Thong P,Benjaroon P, Sangkham N, Wibunjak K, Chai-In P, Chailert S, Thavethanutthanawin P, Promsutt K, Thepkhamkong A, Sithongdeng N, Keovilayvanh M, Khamsoukthavong N, Phanthasomchit P, Phanthavong C, Boualaiseng S, Vongsavang S, Greer RC, Althaus T, Nedsuwan S, Intralawan D, Wangrangsimakul T, Limmathurotsakul D, Ariana P. (BMJ Global Health, 2018-03)

Background: Antimicrobial resistance (AMR) is a global health priority. Leading UK and global strategy papers to fight AMR recognise its social and behavioural dimensions, but current policy responses to improve the ...
Antibody Responses to Crude Gametocyte Extract Predict <i>Plasmodium falciparum</i> Gametocyte Carriage in Kenya

Omondi, BR; Muthui, MK; Muasya, WI; Orindi, B; Mwakubambanya, RS; Bousema, T; Drakeley, C; Marsh, K; Bejon, P; Kapulu, MC (Front Immunol, 2021-01)

Background: Malaria caused by Plasmodium falciparum remains a serious global public health challenge especially in Africa. Interventions that aim to reduce malaria transmission by targeting the gametocyte reservoir are key ...
Antimalarial drugs and the prevalence of mental and neurological manifestations: A systematic review and meta-analysis.

Bitta MA, Kariuki SM, Mwita C, Gwer S, Mwai L, Newton CRJC. (Wellcome Open Res., 2017-06)

Background: Antimalarial drugs affect the central nervous system, but it is difficult to differentiate the effect of these drugs from that of the malaria illness. We conducted a systematic review to determine the association ...
Antimalarials: Review of Plasmepsins as Drug Targets and HIV Protease Inhibitors Interactions

Miller Iii WA, Teye J, Achieng AO, Mogire RM, Akala H, Ong'echa JM, Rathi B, Durvasula R, Kempaiah P, Kwofie SK (Bentham Science, 2019)

Malaria is a major global health concern with the majority of cases reported in regions of South-East Asia, Eastern Mediterranean, Western Pacific, the Americas, and Sub-Saharan Africa. The World Health Organization (WHO) ...
Antimicrobial resistance among children in subSaharan Africa.

Williams PCM, Isaacs D, Berkley JA. (Lancet Infectious Diseases, 2018-02)

Antimicrobial resistance is an important threat to international health. Therapeutic guidelines for empirical treatment of common life-threatening infections depend on available information regarding microbial aetiology ...
Antimicrobial resistance among children in subSaharan Africa.

Williams PCM, Isaacs D, Berkley JA. (Lancet Infectious Diseases, 2018-02)

Antimicrobial resistance is an important threat to international health. Therapeutic guidelines for empirical treatment of common life-threatening infections depend on available information regarding microbial aetiology ...
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.

Taitt CR, Leski TA, Erwin DP, Odundo EA, Kipkemoi NC, Ndonye JN, Kirera RK, Ombogo AN, Walson JL, Pavlinac PB, Hulseberg C, Vora GJ (PLOS One, 2017-06)

We sought to determine the genetic and phenotypic antimicrobial resistance (AMR) profiles of commensal Klebsiella spp. circulating in Kenya by testing human stool isolates of 87 K. pneumoniae and three K. oxytoca collected ...
Antiplasmodial and antileishmanial flavonoids from Mundulea sericea

Chepkirui, Carolyne; Ochieng, Purity J.; Sarkar, Biswajyoti; Hussain, Aabid; Pal, Chiranjib; Yang, Li Jun; Coghi, Paolo; Akala, Hosea; Derese, Solomon; Ndakala, Albert; Heydenreich, Matthias; Wong, Vincent K. W.; Erdélyi, Máté; Yenesew, Abiy (Science Direct, 2021-03)

Five known compounds (1-5) were isolated from the extract of Mundulea sericea leaves. Similar investigation of the roots of this plant afforded an additional three known compounds (6-8). The structures were elucidated using ...
Antiplasmodial prenylated flavanonols from Tephrosia subtriflora.

Muiva-Mutisya LM, Atilaw Y, Heydenreich M, Koch A, Akala HM, Cheruiyot AC, Brown ML, Irungu B, Okalebo FA, Derese S, Mutai C, Yenesew A. (Natural Product Research, 2018-06)

The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and ...
Antiplasmodialprenylated flavanonols from Tephrosia subtriflora.

Muiva-Mutisya LM, Atilaw Y, Heydenreich M, Koch A, Akala HM, Cheruiyot AC,Brown ML, Irungu B, Okalebo FA, Derese S, Mutai C, Yenesew A. (Natural Product Research, 2018-06)

The CH2Cl2/MeOH (1:1) extract of the aerial parts of Tephrosia subtriflora afforded a new flavanonol, named subtriflavanonol (1), along with the known flavanone spinoflavanone B, and the known flavanonols MS-II (2) and ...

Now showing items 1-20 of 421

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