Abstract:
The use of plants for medicinal purposes is an important part of the culture and
tradition in Africa and the world at large. Up to 80% of the world’s population
depends directly on traditional medicine for health care. The main aim of this study
was to determine antimicrobial properties of selected medicinal plants used among
the Kipsigis community in Kenya. The plant materials were collected and taken to
the KEMRI for processing. Four medicinal plants extracts were screened against
selected bacteria and fungi. Inhibition zones diameters, minimum inhibitory
concentrations, phytochemical profile and toxicity of the plants extracts determined.
The most active plant extract against bacteria isolates was C. polycephala hexane
extracts which had an MIC of 3.125 x102 g/ml against methicillin resistant
Staphylococcus aureus. Water extracts of C. polycephala was toxic with CV of
23.75% and 31.56% at 1000mg/ml and 5000mg/ml, respectively. Dichloromethane
extracts of S. didymobotrya killed 80% of mice at a dose of 5000 mg/kg and 40% at
1000 mg/kg. The extracts had different chemical compounds that are responsible for
the activities against the microbes. Significant variability within groups of plants
solvents and organisms at 95% confidence interval (>p 0.05) were found to be
significant. In both the cell and acute toxicity, it was observed that extracts at high
concentration and at a high dose are toxic. The antimicrobial activity of the plants
under investigation demonstrated support for the claimed antimicrobial uses of the
plants in the traditional medicine and provides scientific proof for their medicinal
uses.
