Molecular epidemiology and associated risk factors of rotavirus infection among children < 5 yrs hospitalized for acute gastroenteritis in North Eastern, Kenya, 2012

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dc.contributor.author AHMED MOHAMED FIDHOW
dc.contributor.author Amwayi, Samwel; Ng’ang’a Zipporah; Oundo, Joseph; Nyangao, James; Arvelo, Wences.
dc.date.accessioned 2025-05-07T12:53:36Z
dc.date.available 2025-05-07T12:53:36Z
dc.date.issued 2017
dc.identifier.uri http://www.panafrican-med-journal.com/content/series/28/1/3/full
dc.identifier.uri http://repository.kemri.go.ke:8080/xmlui/handle/123456789/1490
dc.description.abstract Introduction: Rotavirus is a leading cause of morbidity and mortality among children under five years worldwide. This study aimed to characterize the circulating genotypes of rotavirus and to determine risk factors of rotavirus infection in North Eastern, Kenya before the introduction of rotavirus vaccines. Methods: we conducted a cross sectional study among children < 5 years old hospitalized for acute gastroenteritis at the study hospital. Rotavirus was detected in stool specimens and further characterized using PAGE and RT-PCR. Socio-demographic and risk factor information was collected using a standard questionnaire. Results: we enrolled 237 children into the study hospitalized with acute gastroenteritis. Of these, 41 (17%) tested positive for group A rotavirus in stool specimens. Age < 2 years, unboiled tap water, underweight and low birth weight were identified as independent risk factors of rotavirus infection. Majority 8 (57%) of the detected rotavirus RNA profiles were long electropherotypes. G3, G9 and P4 were the predominant genotypes identified. Conclusion: Rotavirus is an important aetiology of acute gastroenteritis among children under five years in this region. Risk factors common in other regions and rotavirus vaccine preventable genotypes are responsible for infection. We recommend the introduction of rotavirus vaccines, coupled with good infant nutrition, safe water supply and maternal hygienic practices during infant feeding. en_US
dc.language.iso en en_US
dc.publisher Pan African Medical Journal en_US
dc.title Molecular epidemiology and associated risk factors of rotavirus infection among children < 5 yrs hospitalized for acute gastroenteritis in North Eastern, Kenya, 2012 en_US
dc.type Article en_US


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