| dc.contributor.author |
Gonçalves BP, Kapulu MC, Sawa P, Guelbéogo WM, Tiono AB, Grignard L, Stone W, Hellewell J, Lanke K, Bastiaens GJH, Bradley J, Nébié I, Ngoi JM, Oriango R, Mkabili D, Nyaurah M, Midega J, Wirth DF, Marsh K, Churcher TS, Bejon P, Sirima SB, Drakeley C, Bousema T. |
|
| dc.description.abstract |
A detailed understanding of the human infectious reservoir is essential for improving
malaria transmission-reducing interventions. Here we report a multi-regional assessment
of population-wide malaria transmission potential based on 1209 mosquito feeding
assays in endemic areas of Burkina Faso and Kenya. Across both sites, we identified 39
infectious individuals. In high endemicity settings, infectious individuals were
identifiable by research-grade microscopy (92.6%; 25/27), whilst one of three infectious
individuals in the lowest endemicity setting was detected by molecular techniques alone.
The percentages of infected mosquitoes in the different surveys ranged from 0.05
(4/7716) to 1.6% (121/7749), and correlate positively with transmission intensity. We
also estimated exposure to malaria vectors through genetic matching of blood from 1094
wild-caught bloodfed mosquitoes with that of humans resident in the same houses.
Although adults transmitted fewer parasites to mosquitoes than children, they received
more mosquito bites, thus balancin |
en_US |