Toll-Like receptors (TLR) are pattern recognition receptors; a component of the innate immune system that are involved in the recognition of pathogen-associated molecular patterns (PAMPs). Recent studies have show that ...
Over the last two decades, malaria prevalence has increased and distribution expanded due to the
spread of multi-drug resistant Plasmodium falciparum.
Following selection of stable piperaquine (PQ) and lumefantrine ...
Cervical cancer is one of the most prevalent types of cancer in women. Every year approximately 0.5 m women are diagnosed with the disease worldwide. Cervical cancer development is linked to the persistent infection by ...
The preservation and recovery of Mycobacterium tuberculosis (MTB) strains isolated from clinical specimens is an important stage in the understanding of issues pertaining to tuberculosis control. Well preserved strains ...
Achieving best practice in management of chronic diseases such as diabetes, which
requires long duration of treatment and multiple therapies, remains a major challenge in
primary health care settings worldwide. As ...
Cancer of the cervix is the second most common cancer in women worldwide and
the leading cause of cancer deaths in women in developing countries. The prevalence
is highest in the developing countries, one of the reasons ...
Antiretroviral drug resistance is a major contributing factor in treatment failure.
Resistance to drugs develops as a result of mutations within the proteins targeted by
drugs. Different HIV-1 subtypes follow different ...
Typhoid fever caused by Salmonella enterica serotype Typhi (S. Typhi) is a
significant cause of morbidity and mortality among children and adults in developing
countries, where the disease burden is high and cost constraints ...
Acute lower respiratory tract infection is a leading cause of morbidity and mortality in children under five years of age in developing countries. Although several investigations have been carried out in Africa and countries ...
Kenya, like other African countries, has been affected significantly by the
HIV/AIDS epidemic. Kenya has been a leader in rapidly expanding access to
HIV prevention, care and treatment, and great effort has been invested ...
Tuberculosis (TB) is yet far from being controlled. Despite the fact that several
reasons could be attributed to this, a significant contributing factor is the development of
resistance to the currently available drugs ...
HIV and AIDS is a major public health concern in the world with 33.2 million
people living with HIV infection by December 2007. Sub-Saharan Africa is the
most affected region in the world where more than two thirds (68%) ...
Pregnant women are more susceptible to malaria than non-pregnant women. This
susceptibility is highest in first and second pregnancies of continuous malaria exposure.
Placental malaria leads to poor birth outcomes and ...
Hepatitis B infection is a disease of the liver caused by Hepatitis B Virus (HBV), a
double-stranded DNA virus coated with an envelope containing Hepatitis B surface
antigens (HBsAg). HBsAg levels in blood are high as ...
Hypertension is one of the major risk factors for stroke, heart failure, kidney failure, eye
disease and premature death. With the advent of Human Immunodeficiency Virus (HIV)
infection and antiretroviral drugs, there ...
Glycoconjugates are molecules which have a carbohydrate moiety bonded to lipids or proteins. Fucosylated glycoconjugates in particular fucosylated oligosaccharides play a significant role in a wide variety of biological ...
HIV/AIDS remains a highly stigmatized disease and a great public health
challenge in Sub-Saharan Africa where majority of the infections (both new
and pre-existing) and deaths occur. As the HIV pandemic continues to ...
O'nyong’nyong fever, caused by infection with a mosquito-borne East African
alphavirus, is an acute, non-fatal illness characterized by fever and polyarthralgia.
Alpha viruses such as Chikungunya and O’nyong’nyong are ...
Understanding the mechanisms that confer protection against progressive infection with
HIV-1 may be useful in the development of appropriate interventions. The impact of
CX3CR1 gene polymorphisms on human immunodeficiency ...
Human African Trypanosomiasis (HAT) or sleeping sickness is an endemic disease in
Southern Sudan including the three States namely; Central, Eastern and Western
Equatoria. The aim of this study was to determine the ...